We have now established that a PhD provides plenty of opportunity to develop mastery and (in many cases) autonomy. Yet, these properties alone do not always ensure a remarkable and satisfying research career. In this second part of the book extract from Newport’s So Good They Can’t Ignore You, we look at an additional piece in the puzzle—having a “mission”—and summarize the book’s system of practices to develop both mastery and mission, which can be applied directly during the PhD. I conclude with some critiques of the book and a case study to test whether these ideas map to my own research career thus far.